Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: longitudinal evaluation of a cohort of prospective brain donors.

Full Abstract

This study presents data on the antemortem evaluations of a cohort of individuals registered in a brain donation program. Clinical evaluation determined that many individuals were unaware they had clinical signs of Parkinson's disease (PD) (rest tremor, bradykinesia, rigidity). Quantitative motor testing (timed tapping test and Purdue pegboard test) revealed a graded reduction in performance in those clinically found to have clinically possible and clinically probable PD. Longitudinal examinations over 4 years revealed some individuals progressed from control to clinically possible PD and clinically possible PD to clinically probable PD. This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing.

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Author information

Author/s: Adler, Charles H (CH); Hentz, Joseph G (JG); Joyce, Jeffrey N (JN); Beach, Thomas (T); Caviness, John N (JN);

Affiliation: Parkinson's Disease and Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA. cadler(-atsign-)mayo.edu

Journal and publication information

Publication Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord), published in England. (Language: eng)

Reference: 2002-Dec; vol 9 (issue 2) : pp 103-10

Dates: Created 2002/12/10; Completed 2003/05/28; Revised 2006/11/15;

PMID: 12473400, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Aged
Aging - physiology
Analysis of Variance
Brain Tissue Transplantation - pathology; statistics & numerical data
Chi-Square Distribution
Cohort Studies
Confidence Intervals
Female
Humans

Humans
Longitudinal Studies
Male
Middle Aged
Motor Skills Disorders - diagnosis; physiopathology
Neuropsychological Tests - statistics & numerical data
Parkinson Disease - diagnosis; physiopathology
Predictive Value of Tests
Prospective Studies
Tissue Donors - statistics & numerical data

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