Research article summary:

Motivation, reward, and Parkinsons disease: influence of dopatherapy.

Abstract Extract:
'Orbitofrontal' and 'cingulate' striatofrontal loops and the mesolimbic dopaminergic system that modulates their function have been implicated in motivation and sensitivity to reinforcement in animals. Parkinsons disease (PD) provides a model to assess ... (Full abstract text below)

Published 2002 in Journal: Neuropsychologia (Language : eng)

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1. Neuropsychologia. 2002 ;40(13):2257-67

Motivation, reward, and Parkinson's disease: influence of dopatherapy.

Czernecki V, Pillon B, Houeto JL, Pochon JB, Levy R, Dubois B

INSERM E 007, Hôpital de la Salpêtrière, Paris, France.

"Orbitofrontal" and "cingulate" striatofrontal loops and the mesolimbic dopaminergic system that modulates their function have been implicated in motivation and sensitivity to reinforcement in animals. Parkinson's disease (PD) provides a model to assess their implications in humans. The aims of the study were to investigate motivation and sensitivity to reinforcement in non-demented and -depressed PD patients and to evaluate the influence of dopaminergic therapy by comparing patients in "on" (with L-Dopa) and "off" (without L-Dopa) states. Twenty-three PD patients were compared, in both the "on" and "off" states, to 28 controls, using: (1) an Apathy Scale; (2) Stimulus-Reward Learning, Reversal, and Extinction tasks; and (3) a Gambling task. PD patients were found: (1) mildly apathetic; (2) impaired on Stimulus-Reward Learning and Reversal, but not on Extinction; and (3) able to progress in the Gambling task during the first, but not the second assessment. There was no significant correlation between these various deficits. L-Dopa treatment clearly improved motivation, but had more limited and contrasting effects on other variables, decreasing the number of omission errors in Reversal, but increasing the number of perseveration errors in Extinction. These results suggest: (1) an implication of striatofrontal loops in human motivation and explicit and implicit sensitivity to reinforcement; (2) a positive influence of L-Dopa treatment on the subjective evaluation of motivation, but contrasting effects on reward sensitivity.

PMID : 12417456 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
V	Czernecki	V
B	Pillon	B
J L	Houeto	JL
J B	Pochon	JB
R	Levy	R
B	Dubois	B

Affiliation: INSERM E 007, Hôpital de la Salpêtrière, Paris, France.

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MESH categories and related page links

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Category links from this article:

Adult
Antiparkinson Agents - therapeutic use
Cognition Disorders - diagnosis
Corpus Striatum - physiopathology
Depressive Disorder, Major - etiology
Extinction, Psychological
Female
Frontal Lobe - physiopathology
Humans
Levodopa - therapeutic use
Male
Motivation
Nerve Net - physiopathology
Neuropsychological Tests
Parkinson Disease - drug therapy, physiopathology, psychology
Reinforcement (Psychology)
Reward

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