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| Research article summary (published 27 Feb 2002): |
Mossy cells in epilepsy: rigor mortis or vigor mortis?
Full Abstract
Mossy cells are bi-directionally connected through a positive feedback loop to granule cells, the principal cells of the dentate gyrus. This recurrent circuit is strategically placed between the entorhinal cortex and the hippocampal CA3 region. In spite of their potentially pro-convulsive arrangement with granule cells, mossy cells have not been seriously considered to promote seizures, because mossy cells, allegedly one of the most vulnerable cell types in the entire mammalian brain, have long been 'known' to die en masse in epilepsy. However, new data suggest that rumors of the rapid demise of the mossy cells might have been greatly exaggerated.
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Author information
Author/s: Ratzliff, Annad d H (AH); Santhakumar, Vijayalakshmi (V); Howard, Allyson (A); Soltesz, Ivan (I);
Affiliation: Dept of Anatomy and Neurobiology, University of California, Irvine 92697-1280, USA.
Grants: NS35915 (Agency:United States NINDS)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
Journal: Trends in neurosciences (Trends Neurosci), published in England. (Language: eng)
Reference: 2002-Mar; vol 25 (issue 3) : pp 140-4
Dates: Created 2002/02/19; Completed 2002/04/12; Revised 2007/11/14;
PMID: 11852145, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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