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| Research article summary (published 30 Oct 2002): |
Mood symptoms and cognitive performance in women estrogen users and nonusers and men.
Full Abstract
OBJECTIVES:
Previous studies have suggested sex differences in mood and cognition and that estrogen effects may partially explain such differences. In this study, we explore sex differences for a range of mood symptoms and for neuropsychological performance in men and postmenopausal women and assess the potential influence of estrogen on these measures.
DESIGN:
Cross-sectional study of men and women examining mood, neuropsychological test data, and estrogen replacement therapy (ERT) use.
SETTING:
Outpatient study at an urban teaching hospital with subjects recruited from the community.
PARTICIPANTS:
All subjects (N = 96) were between the ages of 57 and 75 and included 31 women using ERT, 16 non-ERT users, and 49 men. Subjects did not have major depression and were nondemented.
MEASUREMENT:
The three groups were compared according to profile of mood states and neuropsychological performance, and statistical analyses were controlled for socioeconomic status, age, and education level.
RESULTS:
Female ERT users were less depressed and less angry and performed better on measures of verbal fluency and working memory than the other subject groups.
CONCLUSION:
Postmenopausal estrogen use is associated with better mood and cognitive performance on tasks of fluency and working memory. These results suggest that estrogen should be examined as a potentially critical variable influencing late-life sex differences in mood and cognition.
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Author information
Author/s: Miller, Karen J (KJ); Conney, Janet C (JC); Rasgon, Natalie L (NL); Fairbanks, Lynn A (LA); Small, Gary W (GW);
Affiliation: Department of Psychiatry and Biobehavioral Sciences, the Neuropsychiatric Institute, University of California, Los Angeles, CA 90024, USA. kmiller(-atsign-)mednet.ucla.edu
Grants: AG10123 (Agency:United States NIA) ; AG13308 (Agency:United States NIA) ; MH52453, (Agency:United States NIMH) ; MO1 RR00856-21 (Agency:United States NCRR)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Journal of the American Geriatrics Society (J Am Geriatr Soc), published in United States. (Language: eng)
Reference: 2002-Nov; vol 50 (issue 11) : pp 1826-30
Dates: Created 2002/11/04; Completed 2002/12/13; Revised 2008/03/10;
PMID: 12410901, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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