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| Research article summary (published 30 May 2002): |
Molecular pharmacological dissection of short- and long-term memory.
Full Abstract
1. It has been discussed for over 100 years whether short-term memory (STM) is separate from, or just an early phase of, long-term memory (LTM). The only way to solve this dilemma is to find out at least one treatment that blocks STM while keeping LTM intact for the same task in the same animal. 2. The effect of a large number of treatments infused into the hippocampus, amygdala, and entorhinal, posterior parietal or prefrontal cortex on STM and LTM of a one-trial step-down inhibitory avoidance task was studied. The animals were tested at 1.5 h for STM, and again at 24 h for LTM. The treatments were given after training. 3. Eleven different treatments blocked STM without affecting LTM. Eighteen treatments affected the two memory types differentially, either blocking or enhancing LTM alone. Thus, STM is separate from, and parallel to the first hours of processing of, LTM of that task. 4. The mechanisms of STM are different from those of LTM. The former do not include gene expression or protein synthesis; the latter include a double peak of cAMP-dependent protein kinase activity, accompanied by the phosphorylation of CREB, and both gene expression and protein synthesis. 5. Possible cellular and molecular events that do not require mRNA or protein synthesis should account for STM. These might include a hyperactivation of glutamate AMPA receptors, ribosome changes, or the exocytosis of glycoproteins that participate in cell addition.
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Author information
Author/s: Izquierdo, Luciana A (LA); Barros, Daniela M (DM); Vianna, Monica R M (MR); Coitinho, Adriana (A); deDavid e Silva, Tiago (T); Choi, Humberto (H); Moletta, Beatriz (B); Medina, Jorge H (JH); Izquierdo, Ivan (I);
Affiliation: Centro de Memoria, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal: Cellular and molecular neurobiology (Cell Mol Neurobiol), published in United States. (Language: eng)
Reference: 2002-Jun; vol 22 (issue 3) : pp 269-87
Dates: Created 2002/12/09; Completed 2003/01/08; Revised 2006/11/15;
PMID: 12469870, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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