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| Research article summary (published 30 Oct 2002): |
Molecular mechanisms of memory retrieval.
Full Abstract
Memory retrieval is a fundamental component or stage of memory processing. In fact, retrieval is the only possible measure of memory. The ability to recall past events is a major determinant of survival strategies in all species and is of paramount importance in determining our uniqueness as individuals. Most biological studies of memory using brain lesion and/or gene manipulation techniques cannot distinguish between effects on the molecular mechanisms of the encoding or consolidation of memories and those responsible for their retrieval from storage. Here we examine recent findings indicating the major molecular steps involved in memory retrieval in selected brain regions of the mammalian brain. Together the findings strongly suggest that memory formation and retrieval may share some molecular mechanisms in the hippocampus and that retrieval initiates extinction requiring activation of several signaling cascades and protein synthesis.
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Author information
Author/s: Szapiro, German (G); Galante, Julieta M (JM); Barros, Daniela M (DM); Levi de Stein, Miguelina (M); Vianna, Monica R M (MR); Izquierdo, Luciana A (LA); Izquierdo, Ivan (I); Medina, Jorge H (JH);
Affiliation: Instituto de Biologia Celular y Neurociencias, Facultad de Medicina, UBA, Paraguay 2155, piso 3, 1121 Buenos Aires, Argentina.
Journal and publication information
Publication Type: Journal Article; Review
Journal: Neurochemical research (Neurochem Res), published in United States. (Language: eng)
Reference: 2002-Nov; vol 27 (issue 11) : pp 1491-8
Dates: Created 2003/01/06; Completed 2003/03/07; Revised 2005/11/16;
PMID: 12512953, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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