The modulatory effects of dopamine D1 and D2 receptor function on object working memory in humans.

Full Abstract

The role of dopamine D1 and D2 receptors in modulating object working memory in humans is poorly understood. The current study was designed to investigate the effects of D1 and D2 receptor modulation on object working memory. Twelve healthy subjects underwent testing under three conditions (0.05 mg pergolide (D1/D2 receptor agonist), 2.5 mg bromocriptine (D2 receptor agonist) and placebo] in a double-blind, placebo-controlled repeated measures design. Subjects performed the object working memory N-back task pre-drug and 1.5 h and 3 h post-drug administration. Neither pergolide nor bromocriptine had an effect on object working memory performance. These findings suggest that object working memory may not be modulated by D1 and D2 receptors in humans.

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Author information

Author/s: Bartholomeusz, Cali F (CF); Box, Georgia (G); Van Rooy, Cindy (C); Nathan, Pradeep J (PJ);

Affiliation: Neuropsychopharmacology Research Unit, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia.

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article

Journal: Journal of psychopharmacology (Oxford, England) (J Psychopharmacol), published in United States. (Language: eng)

Reference: 2003-Mar; vol 17 (issue 1) : pp 9-15

Dates: Created 2003/04/08; Completed 2003/07/22; Revised 2006/11/15;

PMID: 12680735, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Bromocriptine - pharmacology
Dopamine Agonists - pharmacology
Double-Blind Method
Female
Humans

Humans
Male
Memory, Short-Term - drug effects; physiology
Pergolide - pharmacology
Psychomotor Performance - drug effects
Receptors, Dopamine D1 - agonists; physiology
Receptors, Dopamine D2 - agonists; physiology

Associated Chemicals: Dopamine Agonists (0) ; Receptors, Dopamine D1 (0) ; Receptors, Dopamine D2 (0) ; Bromocriptine (25614-03-3) ; Pergolide (66104-22-1)

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