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| Research article summary (published 29 Sep 2002): |
Modulating limbic-cortical circuits in depression: targets of antidepressant treatments.
Full Abstract
Of potential importance to the development and testing of novel and more effective antidepressant therapies is the noninvasive characterization of requisite brain changes mediating depression remission. A further clinical goal is the identification of pretreatment markers that might eventually inform optimal treatment selection. Toward these objectives, functional neuroimaging studies have described resting-state glucose metabolic and blood flow abnormalities in cortical, subcortical, and limbic regions, including changes with various antidepressant treatments. There is, however, variability in both site and direction of changes across published reports. In this article, a cortical-limbic network model of depression is used to explain this variability. In this approach, network dysfunction combined with ongoing intrinsic compensatory processes is seen to explain the heterogeneity of depressive symptoms observed clinically, as well as variations in pretreatment scan patterns. Furthermore, the synchronized modulation of these dysfunctional cortical-limbic pathways is considered critical for illness remission, regardless of treatment modality. Formal testing of disease-specific and response-specific functional interactions among regions in this depression network using multivariate approaches are discussed, with a perspective aimed at future studies examining treatment nonresponse, relapse risk, and disease vulnerability.Copyright 2002, Elsevier Science (USA). All rights reserved.
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Author information
Author/s: Mayberg, Helen S (HS);
Affiliation: Department of Psychiatry, University of Toronto, Ontario, Canada. bmayberg@rotman-baycrest.on.ca
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal: Seminars in clinical neuropsychiatry (Semin Clin Neuropsychiatry), published in United States. (Language: eng)
Reference: 2002-Oct; vol 7 (issue 4) : pp 255-68
Dates: Created 2002/10/16; Completed 2002/11/18; Revised 2006/11/15;
PMID: 12382208, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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