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| Research article summary (published 30 Jul 2003): |
Mild cognitive impairment: prevalence and predictive validity according to current approaches.
Full Abstract
OBJECTIVES:
Mild cognitive impairment is associated with an increased risk of developing dementia. However, there is no consensus on diagnostic criteria and different concepts have rarely been evaluated in population-based samples. This paper compares the prevalences and predictive validities for different concepts in a population-based study. The aim was to identify a concept with the best relation of sensitivity and specificity in the prediction of dementia.
MATERIAL AND METHODS:
A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing in a three-wave longitudinal study.
RESULTS:
Prevalence rates ranged from 3 to 36% according to the concept applied. Conversion rates to dementia over 2.6 years ranged from 23 to 47%. In addition, receiver operating characteristic curves indicated that all but one concept for mild cognitive impairment could predict dementia.
CONCLUSION:
Mild cognitive impairment is very frequent in older people. Prevalences and predictive validities are highly dependent on the diagnostic criteria applied.
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Author information
Author/s: Busse, A (A); Bischkopf, J (J); Riedel-Heller, S G (SG); Angermeyer, M C (MC); Leipzig Longitudinal Study of the Aged LEILA75+;
Affiliation: Department of Psychiatry, University of Leipzig, Leipzig, Germany. krausem(-atsign-)medizin.uni-leipzig.de
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Acta neurologica Scandinavica (Acta Neurol Scand), published in Denmark. (Language: eng)
Reference: 2003-Aug; vol 108 (issue 2) : pp 71-81
Dates: Created 2003/07/15; Completed 2003/10/03; Revised 2006/11/15;
PMID: 12859282, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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