Research article summary:

Some methodologic issues in analyzing data from a randomized adolescent tobacco and alcohol use prevention trial.

Abstract Extract:
Three issues concerning the design and analysis of randomized behavioral intervention studies are illustrated and discussed within the framework of a tobacco and alcohol prevention trial among migrant Latino adolescents. The first issue arises when ... (Full abstract text below)

Published 2003Apr in Journal: J Clin Epidemiol (Language : eng)

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1. J Clin Epidemiol. 2003 Apr;56(4):332-40

Some methodologic issues in analyzing data from a randomized adolescent tobacco and alcohol use prevention trial.

Slymen DJ, Elder JP, Litrownik AJ, Ayala GX, Campbell NR

Graduate School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-4162, USA. dslymen@mail.sdsu.edu

Three issues concerning the design and analysis of randomized behavioral intervention studies are illustrated and discussed within the framework of a tobacco and alcohol prevention trial among migrant Latino adolescents. The first issue arises when subjects are randomized in clusters rather than individually. Because subject observations cannot be assumed to be independent, information pertaining to the degree of clustering must be reported, and analyses must take the clustering into account. The second issue concerns the impact of compliance to the intervention and the importance of measuring compliance in the experimental and attention-control groups. A compliance analysis should control for participant contact with study personnel. Investigators must consider ways of constructing a compliance measure that is common to both conditions. Third, because outcomes are measured repeatedly over time, we illustrate the importance of assessing the impact of missing-data patterns on outcomes and the extent to which the patterns may modify the treatment effect.

PMID : 12767410 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Donald J	Slymen	DJ
John P	Elder	JP
Alan J	Litrownik	AJ
Guadalupe X	Ayala	GX
Nadia R	Campbell	NR

Affiliation: Graduate School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-4162, USA. dslymen@mail.sdsu.edu

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