Research article summary:

Lack of association between polymorphisms in angiotensin-converting-enzyme and methylenetetrahydrofolate reductase genes and normal cognitive ageing in humans.

Abstract Extract:
The hypothesis that polymorphisms at two candidate genes that code for angiotensin-converting-enzyme (ACE) and methylenetetrahydrofolate reductase (MTHFR) are associated with normal cognitive ageing was tested using a sample (n=536) of healthy ... (Full abstract text below)

Published 2003Aug in Journal: Neurosci Lett (Language : eng)

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1. Neurosci Lett. 2003 Aug;347(3):175-8

Lack of association between polymorphisms in angiotensin-converting-enzyme and methylenetetrahydrofolate reductase genes and normal cognitive ageing in humans.

Visscher PM, Tynan M, Whiteman MC, Pattie A, White I, Hayward C, Wright AF, Starr JM, Whalley LJ, Deary IJ

Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK.

The hypothesis that polymorphisms at two candidate genes that code for angiotensin-converting-enzyme (ACE) and methylenetetrahydrofolate reductase (MTHFR) are associated with normal cognitive ageing was tested using a sample (n=536) of healthy 80-year-old people who were born in 1921 and whose cognitive ability at age 11 was measured in the Scottish Mental Survey 1932. Cognitive ability at age 11 and age 80 was assessed using the Moray House Test. Cognitive ageing was defined as the change in IQ from age 11 to 80. There was no significant association between the tested ACE and MTHFR polymorphisms and IQ score at age 11, IQ at age 80, and IQ change (all P>0.05). The ACE genotypes deviated significantly from Hardy-Weinberg equilibrium proportions (P=0.02), which could indicate that this gene is under selection. Polymorphisms at the two studied genes are unlikely to be risk factors for normal cognitive ageing.

PMID : 12875914 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Peter M	Visscher	PM
Maria	Tynan	M
Martha C	Whiteman	MC
Alison	Pattie	A
Ian	White	I
Caroline	Hayward	C
Alan F	Wright	AF
John M	Starr	JM
Lawrence J	Whalley	LJ
Ian J	Deary	IJ

Affiliation: Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK.

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