 |
| Research article summary (published 30 Dec 2001): |
Iterative versus filtered backprojection reconstruction for statistical parametric mapping of PET activation measurements: a comparative case study.
Full Abstract
The significance of task-induced cerebral blood flow responses, assessed using statistical parametric mapping, depends, among other things, on the signal-to-noise ratio (SNR) of these responses. Generally, positron emission tomography sinograms of H(2)(15)O activation studies are reconstructed using filtered backprojection (FBP). Alternatively, the acquired data can be reconstructed using an iterative reconstruction procedure. It has been demonstrated that the application of iterative reconstruction methods improves image SNR as compared with FBP. The aim of this study was to compare FBP with iterative reconstruction, to assess the statistical power of H(2)(15)O-PET activation studies using statistical parametric mapping. For this case study, PET data originating from a bimanual motor task were reconstructed using both FBP and maximum likelihood expectation maximization (ML-EM), an iterative algorithm. Both resulting data sets were statistically analyzed using statistical parametric mapping. It was found, with this dataset, that the statistical analysis of the iteratively reconstructed data confirm the a priori expected physiological response. In addition, increased Z scores were obtained in the iteratively reconstructed data. In particular, for the expected task-related response, activation of the posterior border of the left angular gyrus, the Z score increased from 3.00 to 3.96. Furthermore, the number of statistically significant clusters doubled while their volume increased by more than 50%. In conclusion, iterative reconstruction has the potential to increase the statistical power in H(2)(15)O-PET activation studies as compared with FBP reconstruction.
Learn Faster Today Improve your study skills
Author information
Author/s: Reinders, A A T S (AA); Paans, A M J (AM); de Jong, B M (BM); den Boer, J A (JA); Willemsen, A T M (AT);
Affiliation: Department of Biological Psychiatry, Groningen University Hospital, 9700 RB Groningen, The Netherlands. a.a.t.s.reinders(-atsign-)pet.azg.nl
Journal and publication information
Publication Type: Journal Article
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2002-Jan; vol 15 (issue 1) : pp 175-81
Dates: Created 2002/01/04; Completed 2002/03/20; Revised 2006/11/15;
PMID: 11771986, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.