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| Research article summary (published 27 Feb 2002): |
An investigation of the value of spin-echo-based fMRI using a Stroop color-word matching task and EPI at 3 T.
Full Abstract
This study examines the value of spin-echo-based fMRI for cognitive studies at the main magnetic field strength of 3 T using a spin-echo EPI (SE-EPI) sequence and a Stroop color-word matching task. SE-EPI has the potential advantage over conventional gradient-echo EPI (GE-EPI) that signal losses caused by dephasing through the slice are not present, and hence although image distortion will be the same as for an equivalent GE-EPI sequence, signal voids will be eliminated. The functional contrast in SE-EPI will be lower than for GE-EPI, as static dephasing effects do not contribute. As an auxiliary experiment interleaved diffusion-weighted and non-diffusion-weighted SE-EPI was performed in the visual cortex to further elucidate the mechanims of functional contrast. In the Stroop experiment activation was detected in all areas previously found using GE-EPI. Additional frontopolar and ventral frontomedian activations were also found, which could not be detected using GE-EPI. The experiments from visual cortex indicated that at 3 T the BOLD signal change has contributions from the extravascular space and larger blood vessels in roughly equal amounts. In comparison with GE-EPI the absence of static dephasing effects would seem to result in a superior intrinsic spatial resolution. In conclusion the sensitivity of SE-EPI at 3 T is sufficient to make it the method of choice for fMR studies that require a high degree of spatial localization or where the requirement is to detect activation in regions affected by strong susceptibility gradients.©2002 Elsevier Science (USA).
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Author information
Author/s: Norris, David G (DG); Zysset, Stefan (S); Mildner, Toralf (T); Wiggins, Christopher J (CJ);
Affiliation: Max-Planck-Institute for Cognitive Neuroscience, Stephanstrasse 1a, D-04103 Leipzig, Germany.
Journal and publication information
Publication Type: Journal Article
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2002-Mar; vol 15 (issue 3) : pp 719-26
Dates: Created 2002/02/18; Completed 2002/04/22; Revised 2004/11/17;
PMID: 11848715, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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