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| Research article summary (published 11 Mar 2003): |
Intravenous amantadine sulphate application improves the performance of complex but not simple motor tasks in patients with Parkinson's disease.
Full Abstract
Intravenous application of amantadine sulphate induces a rapid improvement of motor symptoms in Parkinson's disease (PD), but there are no trials on the efficacy of this compound on bradykinesia, rigidity and tremor in detail in combination with standardized instrumental measurement of tapping and peg insertion abilities. We treated 31 stable non fluctuating PD patients with amantadine, scored motor symptoms of both arms and performed peg insertion and tapping under cued conditions before and after 3 days. Motor symptoms and peg insertion significantly improved in contrast to tapping. Tapping asks for repetitive performance of simple standardized movements, therefore it needs low cognitive efforts. Since peg insertion depends on more complex movements and thus more dopamine dependent cognitive processes, it improved after application of the indirect dopaminomimetic substance amantadine.
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Author information
Author/s: Müller, Thomas (T); Kuhn, Wilfried (W); Schulte, Thorsten (T); Przuntek, Horst (H);
Affiliation: Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany. thomas.mueller(-atsign-)ruhr-uni-bochum.de
Journal and publication information
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)
Reference: 2003-Mar; vol 339 (issue 1) : pp 25-8
Dates: Created 2003/03/05; Completed 2003/05/19; Revised 2006/11/15;
PMID: 12618292, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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