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| Research article summary (published 30 Aug 2003): |
Intraoperative infrared functional imaging of human brain.
Full Abstract
We hypothesized that it would be possible to detect the distribution of cortical activation by using a sensitive, rapid, high-resolution infrared imaging technique to monitor changes in local cerebral blood flow induced by changes in focal cortical metabolism. In a prospective study, we recorded in 21 patients the emission of infrared radiation from the exposed human cerebral cortex at baseline, during language and motor tasks, and during stimulation of the contralateral median nerve using an infrared camera (sensitivity 0.02 degrees C). The language and sensorimotor cortex was identified by standard mapping methods (cortical stimulation, median nerve somatosensory-evoked potential, functional magnetic resonance imaging), which were compared with infrared functional localization. The temperature gradients measured during surgery are dominated by changes in local cerebral blood flow associated with evoked functional activation. The distribution of the evoked temperature changes overlaps with, but extends beyond, functional regions identified by standard mapping techniques. The distribution observed via infrared mapping is consistent with distributed and complex functional representation of the cerebral cortex, rather than the traditional concept of discrete functional loci demonstrated by brief cortical stimulation during surgery and by noninvasive functional imaging techniques. By providing information on the spatial and temporal patterns of sensory-motor and language representation, infrared imaging may prove to be a useful approach to study brain function.
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Author information
Author/s: Gorbach, Alexander M (AM); Heiss, John (J); Kufta, Conrad (C); Sato, Susumo (S); Fedio, Paul (P); Kammerer, William A (WA); Solomon, Jeffrey (J); Oldfield, Edward H (EH);
Affiliation: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke/NIH, Building 10, Bethesda, MD 20892, USA.
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Annals of neurology (Ann Neurol), published in United States. (Language: eng)
Reference: 2003-Sep; vol 54 (issue 3) : pp 297-309
Dates: Created 2003/09/03; Completed 2003/10/23; Revised 2006/11/15;
PMID: 12953262, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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