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| Research article summary (published 30 Jan 2003): |
Intracortical inhibition and facilitation of the response of the diaphragm to transcranial magnetic stimulation.
Full Abstract
Respiratory muscles respond to a subcortical automatic command and to a neocortical voluntary command. In diseases such as stroke or motor neurone disease, an abnormal diaphragmatic response to single transcranial magnetic stimuli can identify a central source for respiratory disorders, but this is not likely to be the case in disorders affecting intracortical inhibitory and facilitatory mechanisms. This study describes the response of the diaphragm to paired transcranial magnetic stimulation. Thirteen normal subjects were studied (age range, 22 to 43 years; 7 men; phrenic conduction, <6.8 msec; latency of diaphragmatic motor evoked potential, <20.5 msec). Motor evoked potentials in response to paired stimulation were obtained in eight subjects only, with the motor threshold in the remaining five subjects too high to absorb the loss of power inherent in the double-stimulation montage. Interstimulus intervals less than 5 msec resulted in a statistically significant inhibition (p < 0.01 for interstimulus intervals of 1 and 3 ms), whereas intervals longer than 6 msec were facilitatory (maximal, 15 msec). The diaphragmatic pattern matched that of the biceps brachii. The authors conclude that it is possible to study intracortical inhibition and facilitation of diaphragmatic control, although not in all subjects. Technical improvement should alleviate current limitations and make paired transcranial magnetic stimulation a tool to study respiratory muscle abnormalities in settings in which intracortical interactions are important, such as movement disorders.
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Author information
Author/s: Demoule, Alexandre (A); Verin, Eric (E); Ross, Ewen (E); Moxham, John (J); Derenne, Jean-Philippe (JP); Polkey, Michael I (MI); Similowski, Thomas (T);
Affiliation: Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, France.
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society (J Clin Neurophysiol), published in United States. (Language: eng)
Reference: 2003-Feb; vol 20 (issue 1) : pp 59-64
Dates: Created 2003/04/09; Completed 2003/05/21; Revised 2006/11/15;
PMID: 12684560, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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