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| Research article summary (published 29 Jun 2003): |
Intracortical inhibition and facilitation are impaired in patients with early Parkinson's disease: a paired TMS study.
Full Abstract
Twelve patients with early Parkinson's disease (PD), none of whom had received any previous L-DOPA treatment, but using other antiparkinsonian drugs, were studied using transcranial magnetic stimulation (TMS). Contralateral and ipsilateral hemispheres were examined, with a focus on the more pronounced parkinsonian symptoms. The conditioning-test TMS paradigm (with a subthreshold conditioning stimulus and a suprathreshold test stimulus) was used through a stimulating round coil. Paired stimuli of short (3, 5 and 7 ms), medium (10, 15 and 20 ms), and long (100, 150, 200 and 250 ms) interstimulus intervals (ISI) were pseudo-randomly mixed with a single stimulus. The first interosseus muscle was used for the motor-evoked potential recordings. Ten healthy subjects (age and sex matched) were studied in the same manner to obtain normative data. When both groups were compared, the significant difference (reduction of the intracortical inhibition and facilitation) between the PD patients and the control group was found at the short and the medium ISI (3, 5, 7, 10, 15 and 20 ms) in both hemispheres (P < 0.05). The longer ISI produced non-significant differences between the two groups in intracortical excitability. There was a non-significant difference in the motor threshold. In conclusion, it can be supposed that both intracortical inhibition and facilitation are impaired in patients with early PD using other antiparkinsonian treatments than L-DOPA or dopamine agonists.
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Author information
Author/s: Bares, M (M); Kanovský, P (P); Klajblová, H (H); Rektor, I (I);
Affiliation: First Department of Neurology and the Movement Disorders Centre, Masaryk University, St Anne's Hospital, Brno, Czech Republic. martin.bares@fnusa.cz
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: European journal of neurology : the official journal of the European Federation of Neurological Societies (Eur J Neurol), published in England. (Language: eng)
Reference: 2003-Jul; vol 10 (issue 4) : pp 385-9
Dates: Created 2003/06/25; Completed 2003/09/16; Revised 2006/11/15;
PMID: 12823490, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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