Research article summary:

Intracerebral sources of human auditory steady-state responses.

Abstract Extract:
The objective of this study was to localize the intracerebral generators for auditory steady-state responses. The stimulus was a continuous 1000-Hz tone presented to the right or left ear at 70 dBSPL. The tone was sinusoidally amplitude-modulated to a ... (Full abstract text below)

Published 2002 in Journal: Brain Topogr (Language : eng)

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1. Brain Topogr. 2002 ;15(2):69-86

Intracerebral sources of human auditory steady-state responses.

Herdman AT, Lins O, Van Roon P, Stapells DR, Scherg M, Picton TW

School of Audiology and Speech Sciences, University of British Columbia, Vancouver, BC, Canada. aherdman@rotman-baycrest.on.ca

The objective of this study was to localize the intracerebral generators for auditory steady-state responses. The stimulus was a continuous 1000-Hz tone presented to the right or left ear at 70 dBSPL. The tone was sinusoidally amplitude-modulated to a depth of 100% at 12, 39, or 88 Hz. Responses recorded from 47 electrodes on the head were transformed into the frequency domain. Brain electrical source analysis treated the real and imaginary components of the response in the frequency domain as independent samples. The latency of the source activity was estimated from the phase of the source waveform. The main source model contained a midline brainstem generator with two components (one vertical and lateral) and cortical sources in the left and right supratemporal plane, each containing tangential and radial components. At 88 Hz, the largest activity occurred in the brainstem and subsequent cortical activity was minor. At 39 Hz, the initial brainstem component remained and significant activity also occurred in the cortical sources, with the tangential activity being larger than the radial. The 12-Hz responses were small, but suggested combined activation of both brainstem and cortical sources. Estimated latencies decreased for all source waveforms as modulation frequency increased and were shorter for the brainstem compared to cortical sources. These results suggest that the whole auditory nervous system is activated by modulated tones, with the cortex being more sensitive to slower modulation frequencies.

PMID : 12537303 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Anthony T	Herdman	AT
Otavio	Lins	O
Patricia	Van Roon	P
David R	Stapells	DR
Michael	Scherg	M
Terence W	Picton	TW

Affiliation: School of Audiology and Speech Sciences, University of British Columbia, Vancouver, BC, Canada. aherdman@rotman-baycrest.on.ca

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