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| Research article summary (published 30 Jan 2003): |
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Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory.
Full Abstract
OBJECTIVE:
Recent studies have indicated that the serotonergic (5-HT) system plays important roles in memory function. However, the specific relationship between 5-HT(1A) receptors and memory function is not clear in the human brain. To clarify this relationship, the authors determined the availability of 5-HT(1A) receptors in the human brain and the relationship between regional receptor binding and memory function.
METHOD:
Using positron emission tomography (PET) with [(11)C]WAY-100635, the authors examined 5-HT(1A) receptors and assessed their relationship with memory function. The 5-HT(1A )agonist tandospirone was then administered to investigate the effect of 5-HT(1A) receptor stimulation on cognitive function and neuroendocrinological response.
RESULTS:
There was a significant negative correlation between explicit memory function and 5-HT(1A) receptor binding localized in the bilateral hippocampus where the postsynaptic 5-HT(1A) receptors are enriched. Furthermore, the administration of tandospirone dose-dependently impaired explicit verbal memory, while other cognitive functions showed no significant changes. The change in memory function paralleled those of body temperature and secretion of growth hormone, which were reported to be induced by the stimulation of postsynaptic 5-HT(1A) receptors.
CONCLUSIONS:
Postsynaptic 5-HT(1A )receptors localized in the hippocampal formation have a negative influence on explicit memory function, which raises the possibility that the antagonistic effect of postsynaptic 5-HT(1A) receptors in the hippocampus leads to improvement of human memory function. Drugs that work as antagonists on postsynaptic 5-HT(1A) receptors may be favorable for improved control of memory impairment.
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Author information
Author/s: Yasuno, Fumihiko (F); Suhara, Tetsuya (T); Nakayama, Takashi (T); Ichimiya, Tetsuya (T); Okubo, Yoshiro (Y); Takano, Akihiro (A); Ando, Tomomichi (T); Inoue, Makoto (M); Maeda, Jun (J); Suzuki, Kazutoshi (K);
Affiliation: Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan.
Journal and publication information
Publication Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal: The American journal of psychiatry (Am J Psychiatry), published in United States. (Language: eng)
Reference: 2003-Feb; vol 160 (issue 2) : pp 334-40
Dates: Created 2003/02/03; Completed 2003/03/04; Revised 2007/11/15;
PMID: 12562581, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
CommentIn: Am J Psychiatry. 2004 Aug;161(8):1505; author reply 1505-6. (PMID: 15285993)
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