Research article summary:

Inhibition in children with attention-deficit/hyperactivity disorder: a psychophysiological study of the stop task.

Abstract Extract:
BACKGROUND: The purpose of the study was to investigate and identify abnormal brain activity, as revealed by event-related potentials (ERPs) concurring with deficient inhibitory control in children with attention-deficit/hyperactivity disorder (ADHD). ... (Full abstract text below)

Published 2002Apr in Journal: Biol Psychiatry (Language : eng)

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1. Biol Psychiatry. 2002 Apr;51(8):668-76

Inhibition in children with attention-deficit/hyperactivity disorder: a psychophysiological study of the stop task.

Overtoom CC, Kenemans JL, Verbaten MN, Kemner C, van der Molen MW, van Engeland H, Buitelaar JK, Koelega HS

Faculty of Pharmacy, Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.

BACKGROUND: The purpose of the study was to investigate and identify abnormal brain activity, as revealed by event-related potentials (ERPs) concurring with deficient inhibitory control in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Performance and ERPs from 16 children with ADHD and 16 control subjects were compared in the stop-signal paradigm. RESULTS: The ADHD children showed a lower inhibition percentage and their (estimated) response time to the stop signal was disproportionally longer compared to the slowing of reaction times to primary-task stimuli. In normal control subjects, fronto-central positivity (100-400 msec) after the onset of the stop-signal was larger in case of successful inhibition, relative to failed inhibition; this was less so in ADHD children. A late positive wave (500-700 msec), maximal at Oz on failed inhibition trials, and possibly related to error-detection, was smaller in ADHD children. CONCLUSIONS: These results point to abnormalities in brain processes involved in motor inhibition and error-detection in ADHD children.

PMID : 11955467 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Carin C E	Overtoom	CC
J Leon	Kenemans	JL
Marinus N	Verbaten	MN
Chantal	Kemner	C
Maurits W	van der Molen	MW
Herman	van Engeland	H
Jan K	Buitelaar	JK
Harry S	Koelega	HS

Affiliation: Faculty of Pharmacy, Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.

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Category links from this article:

Attention Deficit Disorder with Hyperactivity - diagnosis, physiopathology, psychology
Case-Control Studies
Child
Electroencephalography
Evoked Potentials
Female
Humans
Inhibition (Psychology)
Male
Reaction Time
Task Performance and Analysis

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