 |
| Research article summary (published 30 Dec 2002): |
Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression.
Full Abstract
BACKGROUND:
Neurobiologic abnormalities in the temporal lobe, particularly medial temporolimbic circuits, have been implicated in the pathogenesis of major depressive disorder (MDD). Although MDD commonly emerges during childhood and adolescence, to our knowledge, no prior study has examined temporal lobe anatomy in pediatric patients with MDD near the onset of illness before treatment.
METHODS:
Volumetric magnetic resonance imaging scans were conducted in 23 psychotropic drug-naïve pediatric patients with MDD, aged 8-17 years, and 23 case-matched healthy comparison subjects.
RESULTS:
Pediatric patients with MDD had significantly larger left (14%) and right (11%) amygdala:hippocampal volume ratios than controls. Increased left and right amygdala:hippocampal volume ratios were associated with increased severity of anxiety but not increased severity of depression or duration of illness.
CONCLUSION:
These results suggest that alterations in amygdala:hippocampal volume ratios in pediatric MDD may more reflect severity of associated anxiety than depression. These results underscore the importance of assessment for comorbidity in the study of MDD.
Learn Faster Today Improve your study skills
Author information
Author/s: MacMillan, Shauna (S); Szeszko, Philip R (PR); Moore, Gregory J (GJ); Madden, Rachel (R); Lorch, Elisa (E); Ivey, Jennifer (J); Banerjee, S Preeya (SP); Rosenberg, David R (DR);
Affiliation: Department of Psychiatry, 9B, Wayne State University School of Medicine, 4201 St. Antoine Boulevard, Detroit, MI 48201, USA.
Grants: MH 01372 (Agency:United States NIMH) ; MH 01990 (Agency:United States NIMH) ; MH 02037 (Agency:United States NIMH) ; MH 59299 (Agency:United States NIMH)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Journal of child and adolescent psychopharmacology (J Child Adolesc Psychopharmacol), published in United States. (Language: eng)
Reference: 2003-; vol 13 (issue 1) : pp 65-73
Dates: Created 2003/06/13; Completed 2003/09/09; Revised 2007/11/14;
PMID: 12804127, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.