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| Research article summary (published 30 Oct 2002): |
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Increased amygdala activation to angry and contemptuous faces in generalized social phobia.
Full Abstract
BACKGROUND:
Generalized social phobia (GSP) is characterized by fear of social interactions and sensitivity to disapproval by others. Given the established role of the amygdala as part of a distributed neural system for the processing of emotional cues, we hypothesized that subjects with GSP would exhibit greater amygdala activation in response to harsh (angry, fearful, and contemptous) vs accepting (happy) facial emotional expressions compared with healthy control subjects (HCs).
METHODS:
Fifteen subjects with DSM-IV GSP and 15 age-, sex-, handedness-, and education-matched HCs, free of psychotropic medication for at least 12 weeks, viewed 60 color photographs from a standardized set of human facial stimuli, during which the task was to identify the sex of the person in the photograph. Data were collected across 3 functional (echo-planar) runs using a Siemens 1.5-T magnet, and analyzed using Analysis of Functional Neuroimaging software (Medical College of Wisconsin, Milwaukee).
RESULTS:
In the left allocortex (including the amygdala, uncus, and parahippocampal gyrus), subjects with GSP produced a significantly greater percent blood oxygen level-dependent signal change than did HCs for contemptous compared with happy faces (GSP:
0.72% vs
HC:
-0.01%; F(1,29) = 9.56, P =.004, Cohen d = 1.15) and for angry compared with happy faces (GSP:
0.45% vs
HC:
-0.09%; F(1,29) = 6.78, P =.02, Cohen d = 1.00). Subjects with GSP and HCs did not produce a statistically different percent signal change for fearful or nonexpressive faces compared with the happy faces in this region.
CONCLUSIONS:
These findings are consistent with a role for differential amygdala (and associated limbic) functioning in GSP. The pronounced response to contemptuous and angry facial expressions suggests that the amygdala in GSP may be particularly active in the processing of disorder-salient stimuli.
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Author information
Author/s: Stein, Murray B (MB); Goldin, Philippe R (PR); Sareen, Jitender (J); Zorrilla, Lisa T Eyler (LT); Brown, Gregory G (GG);
Affiliation: Department of Psychiatry, University of California-San Diego, CA 92093-0985, USA. mstein(-atsign-)ucsd.edu
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Archives of general psychiatry (Arch Gen Psychiatry), published in United States. (Language: eng)
Reference: 2002-Nov; vol 59 (issue 11) : pp 1027-34
Dates: Created 2002/11/06; Completed 2002/12/04; Revised 2006/11/15;
PMID: 12418936, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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