Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women.

Full Abstract

OBJECTIVE:
This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood.

METHOD:
Ten postmenopausal subjects underwent positron emission tomography measurements of 5-HT(2A) receptor binding with [(18)F]deuteroaltanserin before and after estrogen replacement therapy.

RESULTS:
5-HT(2A) receptor binding was significantly increased after estrogen replacement therapy in the right prefrontal cortex (right precentral gyrus [Brodmann's area 9], inferior frontal gyrus [Brodmann's area 47], medial frontal gyrus [Brodmann's area 6, 10] and the anterior cingulate cortex [Brodmann's area 32]). In the inferior frontal gyrus [Brodmann's area 44]), receptor up-regulation was correlated with change in plasma estradiol. Verbal fluency and Trail Making Test performance, but not mood, were significantly improved by estrogen without correlation with receptor changes.

CONCLUSIONS:
Estrogen increases 5-HT(2A) receptor binding in human prefrontal regions.

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Author information

Author/s: Kugaya, Akira (A); Epperson, C Neill (CN); Zoghbi, Sami (S); van Dyck, Christopher H (CH); Hou, Yankun (Y); Fujita, Masahiro (M); Staley, Julie K (JK); Garg, Pradeep K (PK); Seibyl, John P (JP); Innis, Robert B (RB);

Affiliation: Department of Psychiatry, Yale University, New Haven, Conn 06516, USA. akira(-atsign-)kugaya(-atsign-)yale.edu

Journal and publication information

Publication Type: Clinical Trial; Comparative Study; Journal Article

Journal: The American journal of psychiatry (Am J Psychiatry), published in United States. (Language: eng)

Reference: 2003-Aug; vol 160 (issue 8) : pp 1522-4

Dates: Created 2003/08/05; Completed 2003/09/05; Revised 2006/11/15;

PMID: 12900319, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Am J Psychiatry. 2004 Nov;161(11):2136; author reply 2136. (PMID: 15514428)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Administration, Cutaneous
Adult
Aged
Estradiol - administration & dosage; blood; therapeutic use
Estrogen Replacement Therapy
Female
Fluorine Radioisotopes - diagnostic use
Follow-Up Studies
Humans
Ketanserin - analogs & derivatives; diagnostic use

Middle Aged
Neuropsychological Tests
Postmenopause - drug effects; psychology
Prefrontal Cortex - chemistry; metabolism; radionuclide imaging
Psychomotor Performance
Pyramidal Cells - chemistry; metabolism; radionuclide imaging
Receptor, Serotonin, 5-HT2A
Receptors, Serotonin - analysis; drug effects; metabolism
Tomography, Emission-Computed
Treatment Outcome

Associated Chemicals: Fluorine Radioisotopes (0) ; Receptor, Serotonin, 5-HT2A (0) ; Receptors, Serotonin (0) ; Estradiol (50-28-2) ; Ketanserin (74050-98-9) ; altanserin (76330-71-7)

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