 |
| Research article summary (published 30 Aug 2002): |
Improvement in cognitive functioning in patients with first-episode psychosis during treatment with quetiapine: an interim analysis.
Full Abstract
BACKGROUND:
The efficacies of second-generation antipsychotic medications in reducing symptoms are reasonably well-documented, but their effects on cognition are less clearly understood.
AIMS:
To under take an interim analysis of an open label, 2-year study examining the effects of quetiapine on cognition in patients with a first episode of schizophrenia and related disorders.
METHOD:
Cognitive testing was performed before quetiapine was initiated and repeated after 3, 6 and 12 months of treatment. To date, 13 patients have been fully assessed (mean dose 517.9 mg/day; s.d. = 225.8).
RESULTS:
Statistically significant improvement was noted on measures of attention (Continuous Performance Test; CPT), verbal productivity (Verbal Fluency Test) and executive function (Object Alternation Test) after 6 and 12 months of treatment. For the CPT, improvement was also noted after 3 months of treatment.
CONCLUSIONS:
During treatment for 1 year with quetiapine, cognitive performance was improved in young patients with psychosis. Continued controlled investigations of the effects of quetiapine on cognition are desirable.
Learn Faster Today Improve your study skills
Author information
Author/s: Good, K P (KP); Kiss, I (I); Buiteman, C (C); Woodley, H (H); Rui, Q (Q); Whitehorn, D (D); Kopala, L (L);
Affiliation: Department of Psychiatry, Dalhousie University, Suite 3073-AJLB, 5909 Veterans' Memorial Lane, Halifax, Nova Scotia, Canada B3H 2E2. kimpgood(-atsign-)is.dal.ca
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The British journal of psychiatry. Supplement (Br J Psychiatry Suppl), published in England. (Language: eng)
Reference: 2002-Sep; vol 43 (issue ) : pp s45-9
Dates: Created 2002/09/25; Completed 2002/11/22; Revised 2008/02/22;
PMID: 12271800, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.