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| Research article summary (published 30 Jan 2003): |
The importance of cochlear processing for the formation of auditory brainstem and frequency following responses.
Full Abstract
A model for the generation of auditory brainstem responses (ABR) and frequency following responses (FFRs) is presented. The model is based on the concept introduced by Goldstein and Kiang [J. Acoust. Soc. Am. 30, 107-114 (1958)] that evoked potentials recorded at remote electrodes can theoretically be given by convolution of an elementary unit waveform (unitary response) with the instantaneous discharge rate function for the corresponding unit. In the present study, the nonlinear computational auditory-nerve model recently developed by Heinz et al. [ARLO 2(3), 91-96 (2001)] was used to calculate the instantaneous discharge rate ri(t) for fibers i in the frequency range from 0.1 and 10 kHz. The summed activity across frequency was convolved with a unitary response which is assumed to reflect contributions from different cell populations within the auditory brainstem, recorded at a given pair of electrodes on the scalp. Predicted potential patterns are compared with experimental data for a number of stimulus and level conditions. Clicks, chirps as defined in Dau et al. [J. Acoust. Soc. Am. 107, 1530-1540 (2000)], long-duration stimuli comprising the chirp, as well as tones and slowly varying tonal sweeps were considered. The results demonstrate the importance of considering the effects of the basilar-membrane traveling wave and auditory-nerve processing for the formation of ABR and FFR. Specifically, the results support the hypothesis that the FFR to low-frequency tones represents synchronized activity mainly stemming from mid- and high-frequency units at more basal sites, and not from units tuned to frequencies around the signal frequency.
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Author information
Author/s: Dau, Torsten (T);
Affiliation: Carl von Ossietzky Universitat Oldenburg, Medizinische Physik, D-26111 Oldenburg, Germany. torsten.dau(-atsign-)medi.physik.uni-oldenburg.de
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The Journal of the Acoustical Society of America (J Acoust Soc Am), published in United States. (Language: eng)
Reference: 2003-Feb; vol 113 (issue 2) : pp 936-50
Dates: Created 2003/02/24; Completed 2003/04/23; Revised 2007/11/15;
PMID: 12597187, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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