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| Research article summary (published 21 Apr 2003): |
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Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures.
Full Abstract
Habituation of the neural response to repeated stimuli has been well demonstrated for subcortical limbic regions responding to emotionally salient stimuli. Although the rostral or affective division of the anterior cingulate cortex (rACC) is also engaged during emotional processing, little is known about the temporal dynamics of this region in sustained evaluation of emotional salience. Using a test/retest design, the present study assessed habituation in the human brain with functional magnetic resonance imaging. Eight healthy subjects were exposed to two repeated runs of aversive, neutral, and blank images. Activation of the rACC to negatively valenced pictures occurred only in the first session, and this activation was significantly greater in the first relative to the second session. Additionally, medial prefrontal cortex, hippocampal, and amygdalar activations were noted during the first, but not second, presentation of aversive pictures. These findings highlight the phasic activity of the rACC in emotional processing consistent with habituation.
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Author information
Author/s: Phan, K Luan (KL); Liberzon, Israel (I); Welsh, Robert C (RC); Britton, Jennifer C (JC); Taylor, Stephan F (SF);
Affiliation: Department of Psychiatry, University of Michigan, Ann Arbor, Ann Arbor, MI, USA. luan@umich.edu
Grants: K08 MH01258 (Agency:United States NIMH)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Neuropsychopharmacology), published in United States. (Language: eng)
Reference: 2003-Jul; vol 28 (issue 7) : pp 1344-50
Dates: Created 2003/06/26; Completed 2003/09/02; Revised 2007/11/14;
PMID: 12784119, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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