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| Research article summary (published 30 Jul 2003): |
Group imaging of task-related changes in cortical synchronisation using nonparametric permutation testing.
Full Abstract
Synthetic aperture magnetometry (SAM) is a nonlinear beamformer technique for producing 3D images of cortical activity from magnetoencephalography data. We have previously shown how SAM images can be spatially normalised and averaged to form a group image. In this paper we show how nonparametric permutation methods can be used to make robust statistical inference about group SAM data. Data from a biological motion direction discrimination experiment were analysed using both a nonparametric analysis toolbox (SnPM) and a conventional parametric approach utilising Gaussian field theory. In data from a group of six subjects, we were able to show robust group activation at the P < 0.05 (corrected) level using the nonparametric methods, while no significant clusters were found using the conventional parametric approach. Activation was found using SnPM in several regions of right occipital-temporal cortex, including the superior temporal sulcus, V5/MT, the fusiform gyrus, and the lateral occipital complex.
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Author information
Author/s: Singh, Krish D (KD); Barnes, Gareth R (GR); Hillebrand, Arjan (A);
Affiliation: The Wellcome Trust Laboratory for MEG Studies, Neurosciences Research Institute, Aston University, Birmingham B4 7ET, England, UK. k.d.singh@aston.ac.uk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: NeuroImage (Neuroimage), published in United States. (Language: eng)
Reference: 2003-Aug; vol 19 (issue 4) : pp 1589-601
Dates: Created 2003/09/01; Completed 2003/10/23; Revised 2006/11/15;
PMID: 12948714, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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