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| Research article summary (published 27 Feb 2002): |
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Greater loss of 5-HT(2A) receptors in midlife than in late life.
Full Abstract
OBJECTIVE:
Earlier work has shown markedly lower density of serotonin 2A (5-HT(2A)) receptors in elderly subjects than in young healthy subjects. In this study the authors used positron emission tomography (PET) and [(18)F]altanserin, a ligand with high affinity for the 5-HT(2A) receptor, to examine the relationship between 5-HT(2A) receptor density and age in more detail.
METHOD:
The 22 subjects ranged in age from 21 to 69 years (mean=43.4, SD=13.3) and were healthy comparison subjects in a study of depression. Regions of interest were determined on magnetic resonance images and were transferred to coregistered PET data. The data were derived from dynamic PET scanning and arterial sampling with resulting plasma activity data corrected for labeled metabolites. Compartmental modeling was used to estimate the radioligand distribution volume. By comparing the distribution volume (DV) of different regions to the cerebellum distribution volume, DV(ratio)-1, which is proportional to the binding potential, was calculated.
RESULTS:
The decrease in 5-HT(2A) binding was not linear but on average was approximately 17% per decade from age 20. The correlations between age and 5-HT(2A) DV(ratio)-1 were significant for the global measure and for the medial gyrus rectus, anterior cingulate, posterior medial prefrontal cortex, hippocampus, and occipital cortex. Most of the fall off in receptor binding occurred up through midlife, and there was less decrease in late life. There were no decreases in regional brain volumes of corresponding magnitudes.
CONCLUSIONS:
5-HT(2A) receptor binding decreases dramatically in a variety of brain regions up through midlife.
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Author information
Author/s: Sheline, Yvette I (YI); Mintun, Mark A (MA); Moerlein, Stephen M (SM); Snyder, Abraham Z (AZ);
Affiliation: Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110-1093, USA. yvette@npg.wustl.edu
Grants: MH-01370 (Agency:United States NIMH) ; MH-54731 (Agency:United States NIMH) ; MH-58444 (Agency:United States NIMH) ; RR-00036 (Agency:United States NCRR)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal: The American journal of psychiatry (Am J Psychiatry), published in United States. (Language: eng)
Reference: 2002-Mar; vol 159 (issue 3) : pp 430-5
Dates: Created 2002/02/28; Completed 2002/03/14; Revised 2007/11/14;
PMID: 11870007, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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