Goals in symptomatic pharmacologic management of frontotemporal lobar degeneration.

Full Abstract

This review ofpharmacotherapyforfrontotemporal lobar degeneration describes the chemical rationale for agents used and reports observed responses to psychotropic medications. Paroxetine addressed anxiety and repetitive, ritualistic behaviors. Depression was resistant to treatment. Valproic acid and quetiapine calmed agitated subjects without exacerbating Parkinsonism. Donepezil has not emerged as a beneficial medication for this group of subjects. Behavioral disturbances can be alleviatedpharmacologically, but further research might determine guidelines for management of this non-Alzheimer's dementia syndrome that could decrease the frequency of adverse drug events.

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Author information

Author/s: Chow, Tiffany W (TW); Mendez, Mario F (MF);

Affiliation: University of Southern California at Los Angeles, USA.

Grants: 5P30AG010123-03 (Agency:United States NIA) ; AG10123 (Agency:United States NIA)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: American journal of Alzheimer's disease and other dementias (Am J Alzheimers Dis Other Demen), published in United States. (Language: eng)

Reference: -2002 Sep-Oct; vol 17 (issue 5) : pp 267-72

Dates: Created 2002/10/23; Completed 2003/02/26; Revised 2007/11/14;

PMID: 12392261, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Aged, 80 and over
Dementia - complications
Depressive Disorder - drug therapy; etiology
Female

Goals
Humans
Male
Middle Aged
Psychotropic Drugs - therapeutic use

Associated Chemicals: Psychotropic Drugs (0)

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