 |
| Research article summary (published 30 Oct 2002): |
Glutamate uptake in synaptic plasticity: from mollusc to mammal.
Full Abstract
A great deal of research has been directed toward understanding the cellular mechanisms underlying synaptic plasticity and memory formation. To this point, most research has focused on the more "active" components of synaptic transmission:
presynaptic transmitter release and postsynaptic transmitter receptors. Little work has been done characterizing the role neurotransmitter transporters might play during changes in synaptic efficacy. We review several new experiments that demonstrate glutamate transporters are regulated during changes in the efficacy of glutamatergic synapses. This regulation occurred during long-term facilitation of the sensorimotor synapse of Aplysia and long-term potentiation of the Schaffer-collateral synapse of the rat. We propose that glutamate transporters are "co-regulated" with other molecules/processes involved in synaptic plasticity, and that this process is phylogenetically conserved. These new findings indicate that glutamate transporters most likely play a more active role in neurotransmission than previously believed.
Learn Faster Today Improve your study skills
Author information
Author/s: Levenson, Jonathan M (JM); Weeber, Edwin J (EJ); Sweatt, J David (JD); Eskin, Arnold (A);
Affiliation: Baylor College of Medicine, Division of Neuroscience, Houston, TX 77030, USA.
Journal and publication information
Publication Type: Journal Article; Review
Journal: Current molecular medicine (Curr Mol Med), published in Netherlands. (Language: eng)
Reference: 2002-Nov; vol 2 (issue 7) : pp 593-603
Dates: Created 2002/11/07; Completed 2003/05/09; Revised 2005/11/16;
PMID: 12420799, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.