 |
| Research article summary (published 29 Nov 2002): |
|
Free Full Text! See links below |
A functional magnetic resonance imaging study of language processing and its cognitive correlates in prematurely born children.
Full Abstract
OBJECTIVE:
Abnormalities in brain structure, cognition, and behavior have been described in children born prematurely. However, no direct in vivo evidence has yet demonstrated abnormal neural processing in these children. Our aim was to compare brain activity associated with phonologic and semantic processing of language between term and preterm children using functional magnetic resonance imaging (fMRI).
METHODS:
fMRI scans were acquired during a passive language comprehension task in 26 preterm children at 8 years of age and in 13 term community control children who were comparable in age, sex, maternal education, and minority status. IQ was assessed using a standard measure of intelligence.
RESULTS:
The pattern of brain activity identified in a semantic processing task in the preterm children closely resembled the pattern of brain activity identified in a phonologic processing task in term controls. The greater this resemblance in the preterm children, the lower their verbal comprehension IQ scores and the poorer their language comprehension during the scanning task.
CONCLUSIONS:
Preterm children with the poorest language comprehension seemed not to fully engage normal semantic processing pathways in a language comprehension task. These children instead engaged pathways that normal term children used to process meaningless phonologic sounds. Aberrant processing of semantic content in these preterm children may account in part for their lower verbal IQ scores.
Learn Faster Today Improve your study skills
Author information
Author/s: Peterson, Bradley S (BS); Vohr, Betty (B); Kane, Michael J (MJ); Whalen, Douglas H (DH); Schneider, Karen C (KC); Katz, Karol H (KH); Zhang, Heping (H); Duncan, Charles C (CC); Makuch, Robert (R); Gore, John C (JC); Ment, Laura R (LR);
Affiliation: Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA. petersob(-atsign-)child.cpmc.columbia.edu
Grants: DC-00493 (Agency:United States NIDCD) ; HD-01994 (Agency:United States NICHD) ; MH01232 (Agency:United States NIMH) ; MH30929 (Agency:United States NIMH) ; MH59139 (Agency:United States NIMH) ; NS 27116 (Agency:United States NINDS) ; NS 35476 (Agency:United States NINDS) ; RR 06022 (Agency:United States NCRR)
Journal and publication information
Publication Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Pediatrics (Pediatrics), published in United States. (Language: eng)
Reference: 2002-Dec; vol 110 (issue 6) : pp 1153-62
Dates: Created 2002/11/28; Completed 2002/12/11; Revised 2007/11/14;
PMID: 12456913, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
Related articles
This article has not been indexed for related articles as yet, however you can still use the live related article search links below.
See a large map of 100+ related articles.