Research article summary:

Functional effects of the DAT1 polymorphism on EEG measures in ADHD.

Abstract Extract:
OBJECTIVE: This paper examines whether dopamine transporter gene (DAT1) allele status mediates medication-related change in cognitive and neurophysiological measures among children with attention-deficiency/hyperactivity disorder (ADHD). METHOD: A single ... (Full abstract text below)

Published 2003Aug in Journal: J Am Acad Child Adolesc Psychiatry (Language : eng)

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1. J Am Acad Child Adolesc Psychiatry. 2003 Aug;42(8):986-93

Functional effects of the DAT1 polymorphism on EEG measures in ADHD.

Loo SK, Specter E, Smolen A, Hopfer C, Teale PD, Reite ML

Department of Psychiatry and Biobehavioral Sciences, UCLA-NPI, Los Angeles, USA. SLoo@mednet.ucla.edu

OBJECTIVE: This paper examines whether dopamine transporter gene (DAT1) allele status mediates medication-related change in cognitive and neurophysiological measures among children with attention-deficiency/hyperactivity disorder (ADHD). METHOD: A single 10-mg dose of methylphenidate was given in a double-blind, placebo-controlled fashion to children with ADHD who were seen for cognitive testing and EEG recording. Buccal samples were obtained and genotyped for the DAT1 polymorphism. RESULTS: DAT1 allele status was associated with performance on a sustained attention task and medication-related EEG changes. Compared with those with one or more copies of the DAT1 9-repeat allele (9R), children with two copies of the 10-repeat allele (10R) exhibited poorer performance on the vigilance task. In addition, children with 10R exhibited medication-related EEG changes of increased central and parietal beta power, decreased right frontal theta power, and lower theta/beta ratios; 9R carriers showed the opposite pattern. CONCLUSIONS: The data suggest that the DAT1 polymorphism mediates medication-related changes in cortical activity among children with ADHD.

PMID : 12874502 [PubMed - Indexed for MEDLINE]

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Full Author Information

First Name	LastName	Initials
Sandra K	Loo	SK
Elaine	Specter	E
Andrew	Smolen	A
Christian	Hopfer	C
Peter D	Teale	PD
Martin L	Reite	ML

Affiliation: Department of Psychiatry and Biobehavioral Sciences, UCLA-NPI, Los Angeles, USA. SLoo@mednet.ucla.edu

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Category links from this article:

Adolescent
Attention Deficit Disorder with Hyperactivity - drug therapy, genetics
Central Nervous System Stimulants - therapeutic use
Child
Cognition Disorders - diagnosis
Dopamine Plasma Membrane Transport Proteins
Double-Blind Method
Electroencephalography
Female
Humans
Male
Membrane Glycoproteins
Membrane Transport Proteins - genetics
Methylphenidate - therapeutic use
Nerve Tissue Proteins
Neuropsychological Tests
Polymorphism, Genetic - genetics

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