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| Research article summary (published 30 Dec 2001): |
First evidence to show the topological change of DNA from B-dNA to Z-DNA conformation in the hippocampus of Alzheimer's brain.
Full Abstract
Alzheimer's disease (AD) is a complex neurodegenerative disorder. Our studies for the first time showed evidence for altered DNA conformation in the hippocampus of Alzheimer's disease affected brain. The Circular dichroism spectra of severely affected AD DNA showed a typical left-handed Z-DNA conformation, whereas normal, young, and aged brain DNA have the usual B-DNA conformation. Moderately affected AD DNA has modified B-DNA conformation (probable B-Z intermediate form). The ELISA, ethidium bromide binding pattern to DNA and melting temperature (Tm) profiles also revealed the conformational transition from B to Z DNA in AD brain DNA. The altered conformation of DNA will have tremendous implications in gene expressions.
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Author information
Author/s: Suram, Anitha (A); Rao, K S Jagannatha (KS); Latha, K S (KS); Viswamitra, M A (MA);
Affiliation: Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore-570013, India.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuromolecular medicine (Neuromolecular Med), published in United States. (Language: eng)
Reference: 2002-; vol 2 (issue 3) : pp 289-97
Dates: Created 2003/03/07; Completed 2003/05/09; Revised 2006/11/15;
PMID: 12622407, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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