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| Research article summary (published 4 Nov 2002): |
Fear memory and the amygdala: insights from a molecular perspective.
Full Abstract
The amygdala modulates memory consolidation and the storage of emotionally relevant information in other brain areas, and itself comprises a site of neural plasticity during aversive learning. These processes have been intensively studied in Pavlovian fear conditioning, a leading aversive learning paradigm that is dependent on the structural and functional integrity of the amygdala. The rapidness and persistence, and the relative ease, with which this conditioning paradigm can be applied to a great variety of species have made it an attractive model for neurochemical and electrophysiological investigations on memory formation. In this review we summarise recent studies which have begun to unravel cellular processes in the amygdala that are critical for the formation of long-term fear memory and have identified molecular factors and mechanisms of neural plasticity in this brain area.
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Author information
Author/s: Stork, Oliver (O); Pape, Hans-Christian (HC);
Affiliation: Institute of Physiology, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. oliver.stork(-atsign-)medizin.uni-magdeburg.de
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
Journal: Cell and tissue research (Cell Tissue Res), published in Germany. (Language: eng)
Reference: 2002-Dec; vol 310 (issue 3) : pp 271-7
Dates: Created 2002/11/28; Completed 2003/08/01; Revised 2006/11/15;
PMID: 12457225, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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