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| Research article summary (published 27 Feb 2003): |
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Familial dementia with Lewy bodies with an atypical clinical presentation.
Full Abstract
The authors report a case of a 64-year-old male with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) pathology at autopsy who did not manifest the core symptoms of DLB until very late in his clinical course. His initial presentation of early executive and language dysfunction suggested a cortical dementia similar to frontotemporal lobar degeneration (FTLD). Core symptoms of DLB including dementia, hallucination, and parkinsonian symptoms were not apparent until late in the course of his illness. Autopsy revealed both brainstem and cortical Lewy bodies and AD pathology. Family history revealed 7 relatives with a history of dementia including 4 with possible or probable DLB. This case is unique because of the FTLD-like presentation, positive family history of dementia, and autopsy confirmation of DLB.
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Author information
Author/s: Bonner, Lauren T (LT); Tsuang, Debby W (DW); Cherrier, Monique M (MM); Eugenio, Charisma J (CJ); Du Jennifer, Q (Q); Steinbart, Ellen J (EJ); Limprasert, Pornprot (P); La Spada, Albert R (AR); Seltzer, Benjamin (B); Bird, Thomas D (TD); Leverenz, James B (JB);
Affiliation: Department of Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, University of Washington, Seattle 98108, USA.
Grants: P50 AG05136 (Agency:United States NIA) ; R01 NS048595-03 (Agency:United States NINDS) ; R01-AG18644 (Agency:United States NIA)
Journal and publication information
Publication Type: Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
Journal: Journal of geriatric psychiatry and neurology (J Geriatr Psychiatry Neurol), published in Canada. (Language: eng)
Reference: 2003-Mar; vol 16 (issue 1) : pp 59-64
Dates: Created 2003/03/18; Completed 2003/07/16; Revised 2007/11/14;
PMID: 12641375, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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