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| Research article summary (published 29 Apr 2002): |
Familial association of neuropsychological traits in patients with generalized and partial seizure disorders.
Full Abstract
To investigate familial effects of neuropsychological deficits associated with seizure disorders, we studied 65 families, in which 1 member had epilepsy. The disorders included childhood absence epilepsy (CAE), juvenile myoclonic epilepsy (JME) and temporal lobe epilepsy (TLE). Age-appropriate tests were administered to assess sustained attention, encoding and verbal memory, executive and focused attention and attentional flexibility/impulsivity. CAE probands attained lower scores than other probands in visual sustained attention and the ability to focus on and execute a visual-motor task. Scores of the unaffected relatives tended to fall between those of the probands and the controls. JME relatives had lower scores than other relatives in tests of visual and auditory sustained attention and attentional flexibility, and showed greater variability in response time. Behavioral information of this type may aid in the specification and differentiation of genetic linkages in affected families.
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Author information
Author/s: Levav, Miriam (M); Mirsky, Allan F (AF); Herault, Judith (J); Xiong, Lan (L); Amir, Naomi (N); Andermann, Eva (E);
Affiliation: Section on Clinical and Experimental Neuropsychology, Laboratory of Brain and Cognition, NIMH, Bethesda, MD 20892, USA.
Journal and publication information
Publication Type: Journal Article
Journal: Journal of clinical and experimental neuropsychology (J Clin Exp Neuropsychol), published in Netherlands. (Language: eng)
Reference: 2002-May; vol 24 (issue 3) : pp 311-26
Dates: Created 2002/05/06; Completed 2002/06/20; Revised 2008/04/14;
PMID: 11992214, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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