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| Research article summary (published 27 Feb 2002): |
Use of a false recognition paradigm in an Alzheimer's disease clinical trial: a pilot study.
Full Abstract
We report the first use of a false recognition memory test in a clinical trial of patients with Alzheimer's disease (AD). Tests of false recognition allow measurement of two components of memory:
the specific details of a prior encounter with a particular item (item-specific recollection) and the general meaning, idea, or gist conveyed by a collection of items (gist memory). We used a false recognition paradigm with categorized pictures to study the effects of an experimental medication in patients with AD. Because medications to treat AD may preferentially improve gist memory or item-specific recollection, use of this type of paradigm may improve sensitivity for detection of drug effects more than standard memory tests.
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Author information
Author/s: Budson, Andrew E (AE); Michalska, Kalina J (KJ); Rentz, Dorene M (DM); Joubert, Claire C (CC); Daffner, Kirk R (KR); Schacter, Daniel L (DL); Sperling, Reisa A (RA);
Affiliation: Harvard Medical School, Boston, Massachusetts, USA. abudson(-atsign-)partners.org
Grants: AG08441 (Agency:United States NIA) ; F32 MH11767 (Agency:United States NIMH) ; K23 MH01870 (Agency:United States NIMH) ; K23 NS02189 (Agency:United States NINDS) ; NS26980 (Agency:United States NINDS)
Journal and publication information
Publication Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
Journal: American journal of Alzheimer's disease and other dementias (Am J Alzheimers Dis Other Demen), published in United States. (Language: eng)
Reference: -2002 Mar-Apr; vol 17 (issue 2) : pp 93-100
Dates: Created 2002/04/16; Completed 2002/10/29; Revised 2007/11/14;
PMID: 11954675, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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