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| Research article summary (published 30 Aug 2002): |
Exercise, experience and the aging brain.
Full Abstract
While limited research is available, evidence indicates that physical and mental activity influence the aging process. Human data show that executive functions of the type associated with frontal lobe and hippocampal regions of the brain may be selectively maintained or enhanced in humans with higher levels of fitness. Similarly enhanced performance is observed in aged animals exposed to elevated physical and mental demand and it appears that the vascular component of the brain response may be driven by physical activity whereas the neuronal component may reflect learning. Recent results have implicated neurogenesis, at least in the hippocampus, as a component of the brain response to exercise, with learning enhancing survival of these neurons. Non-neuronal tissues also respond to experience in the mature brain, indicating that the brain reflects both its recent and its longer history of experience. Preliminary measures of brain function hold promise of increased interaction between human and animal researchers and a better understanding of the substrates of experience effects on behavioral performance in aging.Copyright 2002 Elsevier Science Inc.
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Author information
Author/s: Churchill, James D (JD); Galvez, Roberto (R); Colcombe, Stanley (S); Swain, Rodney A (RA); Kramer, Arthur F (AF); Greenough, William T (WT);
Affiliation: Beckman Institute, University of Illinois at Urbana-Champaign, 405 N Mathews, Urbana, IL 61801, USA.
Grants: AG10154 (Agency:United States NIA) ; AG14966 (Agency:United States NIA) ; MH35321 (Agency:United States NIMH)
Journal and publication information
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
Journal: Neurobiology of aging (Neurobiol Aging), published in United States. (Language: eng)
Reference: -2002 Sep-Oct; vol 23 (issue 5) : pp 941-55
Dates: Created 2002/10/23; Completed 2003/01/10; Revised 2007/11/14;
PMID: 12392797, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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