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Research article summary:
Exercise: a behavioral intervention to enhance brain health and plasticity.
Abstract Extract:
Extensive research on humans suggests that exercise could have benefits for overall health and cognitive function, particularly in later life. Recent studies using animal models have been directed towards understanding the neurobiological bases of these ... (Full abstract text below) Published 2002Jun
in Journal: Trends Neurosci
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. Trends Neurosci.
2002 Jun;25(6):295-301
Exercise: a behavioral intervention to enhance brain health and plasticity.
Cotman CW, Berchtold NC
Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4540, USA. cwcotman@uci.edu
Extensive research on humans suggests that exercise could have benefits for overall health and cognitive function, particularly in later life. Recent studies using animal models have been directed towards understanding the neurobiological bases of these benefits. It is now clear that voluntary exercise can increase levels of brain-derived neurotrophic factor (BDNF) and other growth factors, stimulate neurogenesis, increase resistance to brain insult and improve learning and mental performance. Recently, high-density oligonucleotide microarray analysis has demonstrated that, in addition to increasing levels of BDNF, exercise mobilizes gene expression profiles that would be predicted to benefit brain plasticity processes. Thus, exercise could provide a simple means to maintain brain function and promote brain plasticity.
PMID : 12086747 [PubMed - Indexed for MEDLINE]
This information is obtained from the National Library of Medicine (NLM). Abstract text and other information may be subject to copyright. Type "NLM copyright" into Google for more information.
Full Author Information
| First Name | LastName | Initials |
| Carl W | Cotman | CW |
| Nicole C | Berchtold | NC |
Affiliation: Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4540, USA. cwcotman@uci.edu
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MESH categories and related page links
This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.
Category links from this article:- Acetylcholine - metabolism
- Animals
- Brain - physiology
- Brain-Derived Neurotrophic Factor - analysis, genetics
- Cognition - physiology
- Estrogens - deficiency, physiology
- Exercise
- Gene Expression
- Hippocampus - chemistry, metabolism, physiology
- Humans
- In Situ Hybridization
- Learning - physiology
- Neuronal Plasticity - physiology
- Oligonucleotide Array Sequence Analysis
- Physical Conditioning, Animal
- RNA, Messenger - analysis
- gamma-Aminobutyric Acid - metabolism
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