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| Research article summary (published 30 Aug 2002): |
Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: the West London Study.
Full Abstract
BACKGROUND:
Many studies have demonstrated early generalised cognitive impairment in schizophrenia.
AIMS:
To examine executive function in first-episode schizophrenia, characterise the nature of the impairment and specify any relationships with symptoms and duration of untreated psychosis (DUP).
METHOD:
Patients (n = 136) and normal controls (n = 81) were assessed with the Cambridge Automated Neuropsychological Test Battery, National Adult Reading Test IQ, and Scales for the Assessment of Positive and Negative Symptoms.
RESULTS:
Memory and executive impairments in patients were independent of IQ level. Spatial working memory was impaired because of inadequate strategy use. On a planning task, patients showed reduced planning times and suboptimal problem-solving. On an attentional set-shifting task, 75% of patients were able to perform an extra-dimensional shift thought to be a core attribute of prefrontal cortex function. Those who failed had significantly longer DUP.
CONCLUSIONS:
Prefrontal cortex function deteriorates at the onset of psychosis and continues to worsen over time.
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Author information
Author/s: Joyce, Eileen (E); Hutton, Sam (S); Mutsatsa, Stan (S); Gibbins, Heidi (H); Webb, Emma (E); Paul, Sonja (S); Robbins, Trevor (T); Barnes, Thomas (T);
Affiliation: Imperial College Faculty of Medicine, Charing Cross Site, St Dunstan's Road, London W6 8RP. e.joyce(-atsign-)ic.ac.uk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The British journal of psychiatry. Supplement (Br J Psychiatry Suppl), published in England. (Language: eng)
Reference: 2002-Sep; vol 43 (issue ) : pp s38-44
Dates: Created 2002/09/25; Completed 2002/11/22; Revised 2008/02/22;
PMID: 12271799, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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