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| Research article summary (published 29 Apr 2002): |
Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition.
Full Abstract
This paper focuses on high-frequency (gamma band) EEG activity, the most characteristic electrophysiological pattern in focal seizures of human epilepsy. It starts with recent hypotheses about:
(i) the behaviour of inhibitory interneurons in hippocampal or neocortical networks in the generation of gamma frequency oscillations; (ii) the nonuniform alteration of GABAergic inhibition in experimental epilepsy (reduced dendritic inhibition and increased somatic inhibition); and (iii) the possible depression of GABA(A,fast) circuit activity by GABA(A,slow) inhibitory postsynaptic currents. In particular, these hypotheses are introduced in a new computational macroscopic model of EEG activity that includes a physiologically relevant fast inhibitory feedback loop. Results show that strikingly realistic activity is produced by the model when compared to real EEG signals recorded with intracerebral electrodes. They show that, in the model, the transition from interictal to fast ictal activity is explained by the impairment of dendritic inhibition.
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Author information
Author/s: Wendling, F (F); Bartolomei, F (F); Bellanger, J J (JJ); Chauvel, P (P);
Affiliation: Laboratoire Traitement du Signal et de L'Image, INSERM, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes Cedex, France. fabrice.wendling(-atsign-)univ-rennes1.fr
Journal and publication information
Publication Type: Journal Article
Journal: The European journal of neuroscience (Eur J Neurosci), published in France. (Language: eng)
Reference: 2002-May; vol 15 (issue 9) : pp 1499-508
Dates: Created 2002/05/24; Completed 2002/07/26; Revised 2004/11/17;
PMID: 12028360, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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