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| Research article summary (published 30 Mar 2002): |
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Enhanced semantic priming in schizophrenia: a computer model based on excessive pruning of local connections in association cortex.
Full Abstract
BACKGROUND:
Many studies have found that people with schizophrenia exhibit abnormally high levels of semantic priming. Post-mortem and neuroimaging studies of schizophrenia suggest a reduction of neuritic processes (dendrites and synapses).
AIMS:
To demonstrate that reductions in neuritic processes can produce excessive priming in patients with schizophrenia.
METHOD:
Associative memory was simulated using a computer-based neural network system consisting of two interactive neural groups, one coding for individual memories and the other for the category to which each memory belonged.
RESULTS:
Variation of a single parameter determining the density of local connections within the two neuronal groups gave a close approximation to levels of memory access and semantic priming previously reported in normal subjects and in patients with schizophrenia.
CONCLUSIONS:
This study suggests that schizophrenia arises from excessive pruning of local connections in association cortex. Its findings shed light on the mechanisms underlying cognitive priming more generally, and how it might emerge developmentally.
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Author information
Author/s: Siekmeier, Peter J (PJ); Hoffman, Ralph E (RE);
Affiliation: Department of Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.
Journal and publication information
Publication Type: Journal Article
Journal: The British journal of psychiatry : the journal of mental science (Br J Psychiatry), published in England. (Language: eng)
Reference: 2002-Apr; vol 180 (issue ) : pp 345-50
Dates: Created 2002/04/01; Completed 2002/06/04; Revised 2004/11/17;
PMID: 11925358, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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