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| Research article summary (published 30 Dec 2002): |
Enhanced intensity dependence as a marker of low serotonergic neurotransmission in borderline personality disorder.
Full Abstract
Dysfunction of central serotonergic activity has been assumed in patients with borderline personality disorder (BPD) characterized by a prominent impulsive behavioral style. Following the high serotonergic innervation of the primary auditory cortex, there is increasing evidence of the intensity dependence of auditory evoked potentials (AEP), especially the N1/P2 component, indicating serotonergic neurotransmission in animals and humans. 15 females who met the IPDE-criteria for BPD and a group of comparative healthy females (controls) completed extensive personality questionnaires which gave special regard to impulsiveness. We obtained event-related AEP through the application of various loudness stimuli. We examined the relevant N1/P2 amplitude of the tangential dipole of the auditory evoked response using dipole source analysis. The augmentation of the N1/P2 amplitude of tangential dipole source activity with rising stimulus intensity was significantly pronounced in BPD as opposed to controls, accompanied by a reduction in N1 and P2 latencies. The strong loudness dependency of AEP correlated with aspects of impulsiveness. These data imply reduced inhibiting control over cortical sensory processing in BPD. Our findings contribute a further argument to the hypothesis of low serotonergic neurotransmission in BDP and may point to a trait character of impulsiveness in this personality disorder.
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Author information
Author/s: Norra, Christine (C); Mrazek, Monika (M); Tuchtenhagen, Frank (F); Gobbelé, René (R); Buchner, Helmut (H); Sass, Henning (H); Herpertz, Sabine C (SC);
Affiliation: Department of Psychiatry and Psychotherapy, Medical Faculty of the University of Technology-RWTH Aachen, Pauwelstrasse 30, D-52074 Aachen, Germany. cnorra(-atsign-)ukaachen.de
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal: Journal of psychiatric research (J Psychiatr Res), published in England. (Language: eng)
Reference: -2003 Jan-Feb; vol 37 (issue 1) : pp 23-33
Dates: Created 2002/12/16; Completed 2003/04/29; Revised 2006/11/15;
PMID: 12482467, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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