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| Research article summary (published 20 Aug 2003): |
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Encoding predictive reward value in human amygdala and orbitofrontal cortex.
Full Abstract
Adaptive behavior is optimized in organisms that maintain flexible representations of the value of sensory-predictive cues. To identify central representations of predictive reward value in humans, we used reinforcer devaluation while measuring neural activity with functional magnetic resonance imaging. We presented two arbitrary visual stimuli, both before and after olfactory devaluation, in a paradigm of appetitive conditioning. In amygdala and orbitofrontal cortex, responses evoked by a predictive target stimulus were decreased after devaluation, whereas responses to the nondevalued stimulus were maintained. Thus, differential activity in amygdala and orbitofrontal cortex encodes the current value of reward representations accessible to predictive cues.
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Author information
Author/s: Gottfried, Jay A (JA); O'Doherty, John (J); Dolan, Raymond J (RJ);
Affiliation: Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK. j.gottfried(-atsign-)fil.ion.ucl.ac.uk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)
Reference: 2003-Aug; vol 301 (issue 5636) : pp 1104-7
Dates: Created 2003/08/22; Completed 2003/09/04; Revised 2007/03/19;
PMID: 12934011, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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