Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus.

Full Abstract

We report preliminary results from four patients subjected to hippocampal electrocorticography and microdialysis during temporal lobe epilepsy surgery. In two cases, spontaneously vigorous hippocampal epileptiform activity (EA) was identified; basal dialysate levels for hippocampal glutamate, aspartate, and gamma-aminobutyric acid ranged from approximately 23- to 84-fold, 19- to 33-fold and 10- to 34-fold higher, respectively, compared to the two cases of minimal hippocampal EA. These findings represent the first intraoperative evidence of elevated extracellular levels of neuroactive amino acids within the spontaneously epileptiform human hippocampus.

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Author information

Author/s: Thomas, P M (PM); Phillips, J P (JP); Delanty, N (N); O'Connor, W T (WT);

Affiliation: The National Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland. pthomasmd(-atsign-)softhome.net

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

Journal: Epilepsy research (Epilepsy Res), published in Netherlands. (Language: eng)

Reference: 2003-Apr; vol 54 (issue 1) : pp 73-9

Dates: Created 2003/05/13; Completed 2003/07/21; Revised 2006/11/15;

PMID: 12742599, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Anesthesia, General
Aspartic Acid - metabolism
Electroencephalography
Epilepsy, Temporal Lobe - metabolism; surgery
Female

Glutamic Acid - metabolism
Hippocampus - metabolism; surgery
Humans
Intraoperative Period
Male
gamma-Aminobutyric Acid - metabolism

Associated Chemicals: gamma-Aminobutyric Acid (56-12-2) ; Aspartic Acid (56-84-8) ; Glutamic Acid (56-86-0)

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