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| Research article summary (published 5 Jun 2002): |
Electrophysiological localization of the subthalamic nucleus in parkinsonian patients.
Full Abstract
Deep brain stimulation of the subthalamic nucleus (STN) is becoming the procedure of choice to reduce symptoms of Parkinson's disease such as rigidity, akinesia and tremor. We present here a series of electrophysiological recordings performed in 34 patients along a standardized electrode trajectory. Neuronal activity along the trajectory consists of a first heterogeneous population of thalamic cells with a mean frequency of 24.8+/-1.4 Hz followed by a silent zone and a second population of STN neurones with a significantly higher spiking frequency (P<0.001) of 42.3+/-1.8 Hz. This study confirms previous findings and suggests that rapid measurement of neuronal spiking frequency and burst index is sufficient to determine precisely the vertical position of the STN.
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Author information
Author/s: Pralong, Etienne (E); Ghika, Joseph (J); Temperli, Philippe (P); Pollo, Claudio (C); Vingerhoets, Francois (F); Villemure, Jean-Guy (JG);
Affiliation: Institut de Biologie Cellulaire et Moléculaire, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland. epralong(-atsign-)ibcm.unil.ch
Journal and publication information
Publication Type: Journal Article
Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)
Reference: 2002-Jun; vol 325 (issue 2) : pp 144-6
Dates: Created 2002/06/04; Completed 2002/08/06; Revised 2004/11/17;
PMID: 12044641, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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