|
Research article summary:
Electrophysiological investigation of the effectiveness of methylphenidate in children with and without ADHD.
Abstract Extract:
The Continuous Performance Test (CPT) is an appropriate instrument for assessment of correlates at the brain electrical activity level of attention and response to stimulant medication. The aim of the study was to confirm at the electrophysiological ... (Full abstract text below) Published 2003Jul
in Journal: J Neural Transm
(Language : eng)
Full Pubmed Extract
This information was retrieved, real-time, on your behalf from the public area of the Pubmed website:
1. J Neural Transm.
2003 Jul;110(7):821-9
Electrophysiological investigation of the effectiveness of methylphenidate in children with and without ADHD.
Seifert J, Scheuerpflug P, Zillessen KE, Fallgatter A, Warnke A
EEG-Ep-Mapping Laboratory, Department of Child and Adolescent Psychiatry, University Hospital of Würzburg, Germany. kjp@nervenklinik.uni-wuerzburg.de
The Continuous Performance Test (CPT) is an appropriate instrument for assessment of correlates at the brain electrical activity level of attention and response to stimulant medication. The aim of the study was to confirm at the electrophysiological level the clinical effectiveness of methylphenidate (MPH) in children with attention deficit / hyperactivity disorder (ADHD); to this end, a comparative study of hyperactive and healthy control children was undertaken, employing a modified CPT test. Twenty-one channel ERPs from 17 hyperactive boys, with and without MPH treatment, and from 20 healthy control children were analyzed with reference-independent techniques. The resulting quasi-stabile microstates correspond to the time ranges of the conventional ERP components P100, P200 and P300 (with the subcomponents P3a and P3b) and could be discriminated by means of data-based segmentation. The P3a amplitudes of the hyperactive children, in each case with and without MPH medication, were compared with those of healthy controls. P3a segment amplitudes were significantly lower in non-medicated ADHD patients than in healthy children, both following positive and inhibitory stimulus conditions. A significant medication effect was detected following MPH treatment: segment 3 amplitudes in MPH-treated hyperactive children were not significantly different from those of healthy controls. MPH exerts a highly potent effect on stimulus recognition and resulting consequences. Application of the CPT-OX enables the reliable measurement of electrophysiological correlates of the clinical effectiveness of MPH under different stimulus conditions.
PMID : 12811642 [PubMed - Indexed for MEDLINE]
This information is obtained from the National Library of Medicine (NLM). Abstract text and other information may be subject to copyright. Type "NLM copyright" into Google for more information.
Full Author Information
| First Name | LastName | Initials |
| J | Seifert | J |
| P | Scheuerpflug | P |
| K-E | Zillessen | KE |
| A | Fallgatter | A |
| A | Warnke | A |
Affiliation: EEG-Ep-Mapping Laboratory, Department of Child and Adolescent Psychiatry, University Hospital of Würzburg, Germany. kjp@nervenklinik.uni-wuerzburg.de
3rd Party provider links
Click the links below to go to related 3rd party information:
MESH categories and related page links
This article was linked to the MESH categories shown on the left below. The links on the right are related Memletics pages.
Category links from this article: | | Related Memletics topics: |
Links for this articleFor links to places where you can get the full text of this article see links. Note there may be a subscription or fee required for access to the full text. New! Using similar technology to this site, we have launched find-health-articles.com, targeting over 1 million health research article abstracts. Related ArticlesHere are some articles related to this one (by title keywords): Keywords in this article:activity, adhd, aim, amplitudes, analyzed, application, appropriate, assessment, attention, based, boys, brain, case, channel, children, clinical, comparative, compared, components, conditions, confirm, consequences, continuous, control, controls, conventional, correlates, correspond, cpt, data, deficit, detected, different, discriminated, disorder, effectiveness, electrical, electrophysiological, employing, enables, end, erps, exerts, following, healthy, highly, hyperactive, hyperactivity, independent, inhibitory, instrument, level, lower, means, measurement, medicated, medication, methylphenidate, microstates, modified, mph, non, not, one, ox, patients, performance, positive, potent, quasi, ranges, recognition, reference, reliable, response, resulting, segmentation, significant, stabile, stimulant, stimulus, study, subcomponents, techniques, test, time, treated, treatment, twenty, undertaken
|
