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| Research article summary (published 29 Apr 2002): |
Electrophysiological evidence reveals affective evaluation deficits early in stimulus processing in patients with panic disorder.
Full Abstract
Cognitive and neurobiological accounts of clinical anxiety and depression were examined via event-related brain potentials (ERPs) recorded from patients with panic disorder and healthy controls as they performed an old/new recognition memory task with emotionally negative and neutral words. The emotive connotation of words systematically influenced control subjects' - but not patients' - ERP effects at prefrontal sites in a latency range (to approximately 300-500 ms) generally assumed to reflect greater contribution of automatic than controlled memory processes. This provides evidence for dysfunctional inhibitory modulation of affective information processing in panic disorder. The ERP effects after 700 ms, however, suggest that some patients may adopt conscious strategies to minimize the impact of these early processing abnormalities on overt behaviors.
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Author information
Author/s: Windmann, Sabine (S); Sakhavat, Zoha (Z); Kutas, Marta (M);
Affiliation: Department of Cognitive Science, University of California, San Diego, USA. Sabine.Windmann(-atsign-)ruhr-uni-bochum.de
Grants: AG08313 (Agency:United States NIA) ; HD22614 (Agency:United States NICHD)
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Journal of abnormal psychology (J Abnorm Psychol), published in United States. (Language: eng)
Reference: 2002-May; vol 111 (issue 2) : pp 357-69
Dates: Created 2002/05/10; Completed 2002/06/07; Revised 2007/11/14;
PMID: 12003457, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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