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| Research article summary (published 30 Mar 2003): |
Electrophysiological analysis of context effects in Alzheimer's disease.
Full Abstract
Event-related potentials elicited by semantically associated and unassociated word pairs embedded in congruous and semantically anomalous spoken sentences were recorded from patients with Alzheimer's disease (AD) and healthy older and young controls as a means of examining the nature, time course, and relation between word and sentence context effects. All groups demonstrated lexical priming in nonsensical sentences, but it was earlier in the young (200-600 ms) than in the older controls (600-800 ms), and even later in the probable AD patients (800-1,000 ms). Moreover, processing in both the elderly and AD groups benefited disproportionately from a meaningful sentence context. The results do not accord well with either a strictly structural or a strictly functional account of the semantic impairments in AD.
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Author information
Author/s: Schwartz, Tanya J (TJ); Federmeier, Kara D (KD); Van Petten, Cyma (C); Salmon, David P (DP); Kutas, Marta (M);
Affiliation: Department of Psychology, Rehabilitation Hospital of the Pacific, Honolulu, Hawaii 96817, USA. tanyaschwartz(-atsign-)hawaii.rr.com
Grants: AG05131 (Agency:United States NIA) ; AG08313 (Agency:United States NIA) ; HD22614 (Agency:United States NICHD)
Journal and publication information
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal: Neuropsychology (Neuropsychology), published in United States. (Language: eng)
Reference: 2003-Apr; vol 17 (issue 2) : pp 187-201
Dates: Created 2003/06/13; Completed 2003/07/14; Revised 2007/11/14;
PMID: 12803424, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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