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| Research article summary (published 13 May 2003): |
Effect of age on regional cerebral blood flow patterns in Alzheimer's disease patients.
Full Abstract
The purpose of this study was to explore the influence of age on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer's disease (AD). Single photon emission computed tomography (SPECT) was performed in 79 patients with AD, including 31 younger and 48 older patients divided according to age at examination (<70 and > or = 70 years), and the SPECT data were analyzed using three-dimensional stereotactic surface projection. Although no significant differences in severity and duration of disease between the two groups were found, there were some differences in rCBF patterns. Patients with younger AD had a more severe decrease of rCBF in the parietotemporal and posterior cingulate cortex, while patients with older AD had a more severe decrease of rCBF in the medial temporal region and medial frontal lobe. This observer-independent analysis of SPECT data provides an objective assessment of cortical rCBF abnormalities in patients with AD and is useful in demonstrating the differences in rCBF patterns between younger and older patients with AD.
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Author information
Author/s: Hanyu, Haruo (H); Shimuzu, Takeshi (T); Tanaka, Yuriko (Y); Takasaki, Masaru (M); Koizumi, Kiyoshi (K); Abe, Kimihiko (K);
Affiliation: Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishihsinjuku, Shinjuku, Tokyo, 160-0023, Japan. hanyu(-atsign-)mb.kcom.ne.jp
Journal and publication information
Publication Type: Journal Article
Journal: Journal of the neurological sciences (J Neurol Sci), published in Netherlands. (Language: eng)
Reference: 2003-May; vol 209 (issue 1-2) : pp 25-30
Dates: Created 2003/04/10; Completed 2003/06/16; Revised 2004/11/17;
PMID: 12686398, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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